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Nessa Carey

The Epigenetics Revolution: How Modern Biology is Rewriting Our Understanding of Genetics, Disease and Inheritance

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    The most exciting phrase to hear in science, the one that heralds new discoveries, is not ‘Eureka!’ (I found it!) but ‘That’s funny …’
    Isaac Asimov
  • Vladimir Zivkoviccompartió una citahace 3 años
    There is a well-known scientific proverb: absence of evidence is not the same as evidence of absence.
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    Thomas Henry Huxley. He was Darwin’s great champion in the 19th century and it was Huxley who first described ‘the slaying of a beautiful hypothesis by an ugly fact’.
  • Vladimir Zivkoviccompartió una citahace 3 años
    DNA alone isn’t carrying all the necessary information for the creation of new life. Something else must be required in addition to the genetic information. Something epigenetic.
  • Soliloquios Literarioscompartió una citahace 3 años
    In full-blown cancer the cells don’t just divide too often, they are also abnormal and can start to invade other tissues.

    A mole is a benign tumour. So is a little outgrowth in the inside of the large intestine, called a polyp. Neither a mole nor a polyp is dangerous in itself. The problem is that the more of these moles or polyps you have, the greater the likelihood that one of them will go the next step, and develop an abnormality that will take it further along the path towards full-blown cancer
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    So there is a consistent finding. Our two unrelated compounds, which control growth of cancer cells in culture and which have now been licensed for use in human treatment, inhibit epigenetic enzymes. In doing so, they both drive up gene expression which raises the obvious question of why this is useful for treating cancer.
  • Soliloquios Literarioscompartió una citahace 3 años
    Proto-oncogenes and tumour suppressors are not intrinsically good or bad. In healthy cells, the activities of these two classes of genes balance each other. But when regulation of these networks goes wrong, cell proliferation may become mis-regulated. If a proto-oncogene becomes over-active, it may push a cell towards a cancerous state. Conversely, if a tumour suppressor gets inactivated, it will no longer act as a brake on cell division. The outcome is the same in both cases – the cell may begin to proliferate too rapidly
  • Soliloquios Literarioscompartió una citahace 3 años
    When the DNA of a CpG island is heavily methylated, the gene controlled by that promoter is switched off. In other words, DNA methylation is a repressive modification. DNMT activity increases DNA methylation and therefore represses gene expression
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