Oh, Brother! stars the sibling duo of Bud and Lily, who humorously interact within the leafy confines of their middle-class suburban home and neighborhood. Whether they are playing together in the family room or running amok in the schoolyard, Bud and Lily elevate the act of one-upmanship to Code Red levels. Lily is the quintessential slightly older and far more sensible sister. She takes it upon herself to look after her uninhibited, prank-loving younger brother, Bud. While Lily wins the occasional battle with her cool-headed maturity, Bud is intent on winning the war with his brazen brand of mischief. Despite their obvious differences, Bud and Lily love each other deeply and have a strong sibling bond.